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Michaelis-Menten Parameters of DiFMUP Dephosphorylation by wt and mutant SHP2 under basal conditions.
| Variant | KM (mM) | kcat (s−1) | kcat /KM (M−1 s−1) |
|---|---|---|---|
| wt | 5.8 ± 0.7 | 12.2 ± 1.0 | 2.10 · 103 |
| E76Q | 0.89 ± 0.05 | 63.7 ± 1.4 | 7.12 · 104 |
| F285S | 4.28 ± 0.56 | 61.4 ± 4.9 | 1.43 · 104 |
| S502P | 1.25 ± 0.09 | 95.6 ± 2.8 | 7.65 · 104 |
| PTP | 0.45 ± 0.03 | 134.5 ± 3.0 | 2.98 · 105 |
