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Michaelis-Menten Parameters DiFMUP dephosphorylation by wt and mutant SHP2 under full phosphopeptide stimulation.
| Variant | KM (mM) | kcat (s−1) | kcat /KM (M−1 s−1) |
|---|---|---|---|
| wt | 0.24 ± 0.04 | 119 ± 6.0 | 4.96 · 105 |
| E76Q | 0.14 ± 0.01 | 121 ± 2.0 | 8.64 · 105 |
| F285S | 0.21 ± 0.02 | 121 ± 3.0 | 5.76 · 105 |
| S502P | 0.26 ± 0.02 | 126 ± 3.2 | 4.85 · 105 |
| PTP | 0.22 ± 0.02 | 126 ± 2.4 | 5.73 · 105 |
