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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Mol Nutr Food Res. 2016 Mar 21;60(6):1264–1274. doi: 10.1002/mnfr.201500822

Figure 2. Molecular mechanisms of flavonoids on melanin synthesis.

Figure 2

The current understanding of melanin synthesis follows the cAMP-PKA-MITF-tyrosinase scheme, in which MITF serves as the master transcriptional factor activating tyrosinase, DCT and TYRP-1, and receives signals from MC1R. Inhibitory or stimulatory effects of each compound are listed in the scheme with references discussed in the text.