Table 4.
Cox Model Results for Association of Immune Cell Infiltrates and Outcomes
| Single Variable Results | OS | RFT | DST | |||||
|---|---|---|---|---|---|---|---|---|
| Variable | n | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| CD4 | 10 cell increase | 267 | 0.77 (0.65, 0.93) | 0.005 | 0.83 (0.70, 0.99) | 0.03 | 0.73 (0.56, 0.94) | 0.02 |
| CD8 | 10 cell increase | 270 | 0.77 (0.64, 0.94) | 0.008 | 0.85 (0.72, 1.00) | 0.05 | 0.80 (0.64, 1.01) | 0.06 |
| FOXP3 | 10 cell increase | 272 | 0.82 (0.70, 0.96) | 0.01 | 0.92 (0.81, 1.04) | 0.18 | 0.89 (0.76, 1.06) | 0.19 |
| CD68 | 10 cell increase | 263 | 0.95 (0.81, 1.12) | 0.56 | 1.02 (0.87, 1.20) | 0.77 | 1.01 (0.83, 1.24) | 0.91 |
| CD1A_tumor | uniform | 52 | 0.68 (0.34, 1.35) | 0.27 | 0.56 (0.26, 1.24) | 0.15 | 0.41 (0.14, 1.20) | 0.10 |
| Modest,mostly basal | 90 | 0.84 (0.48, 1.47) | 0.54 | 0.84 (0.48, 1.47) | 0.54 | 0.94 (0.47, 1.89) | 0.86 | |
| none | 105 | ref | ref | ref | ||||
| CD1A_stroma | many cells + | 15 | 0.23 (0.03, 1.71) | 0.15 | 0.49 (0.12, 2.05) | 0.33 | 0.34 (0.05, 2.53) | 0.29 |
| occasional cells + | 30 | 0.94 (0.42, 2.14) | 0.89 | 0.80 (0.33, 1.91) | 0.61 | 0.60 (0.18, 2.01) | 0.41 | |
| no cells + | 122 | ref | ref | ref | ||||
| Multivariable Results | OS | RFT | DST | |||||
| Variable | n | HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | |
| CD4 | 10 cell increase | 267 | 0.70 (0.55, 0.89) | 0.003 | 0.85 (0.70, 1.03) | 0.09 | 0.56 (0.38, 0.83) | 0.004 |
| CD8 | 10 cell increase | 270 | 0.81 (0.67, 0.99) | 0.04 | 0.90 (0.75, 1.07) | 0.22 | 0.85 (0.68, 1.07) | 0.16 |
| FOXP3 | 10 cell increase | 272 | 0.83 (0.69, 1.00) | 0.05 | 0.94 (0.81, 1.09) | 0.41 | 0.87 (0.71, 1.08) | 0.21 |
| CD68 | 10 cell increase | 263 | 1.04 (0.87, 1.24) | 0.65 | 1.10 (0.93, 1.31) | 0.27 | 1.14 (0.92, 1.41) | 0.22 |
| CD1A_tumor | uniform | 52 | 0.94 (0.44, 1.99) | 0.87 | 0.52 (0.22, 1.25) | 0.15 | 0.44 (0.13, 1.51) | 0.19 |
| Modest, mostly basal | 90 | 0.93 (0.51, 1.70) | 0.82 | 0.82 (0.46, 1.48) | 0.51 | 0.89 (0.42, 1.90) | 0.76 | |
| none | 105 | ref | ref | ref | ||||
| CD1A_stroma | many cells + | 15 | 0.22 (0.03, 1.73) | 0.15 | 0.58 (0.13, 2.63) | 0.48 | 0.42 (0.05, 3.41) | 0.41 |
| occasional cells + | 30 | 1.11 (0.44, 2.78) | 0.83 | 0.99 (0.38, 2.56) | 0.98 | 1.17 (0.30, 4.59) | 0.82 | |
| no cells + | 122 | ref | ref | ref | ||||
Hazard ratios for continuous measures are all presented for each 10 cell increase.
Single variable models are Cox proportional hazards models with biomarker alone as a predictor.
Multivariable models are Cox proportional hazards models with biomarker as a predictor controlling for age, clinical stage, disease site, comorbidities, HPV, treatment and smoking in the model.
Definitions: OS=Overall Survival. RFS=Recurrence Free Survival. DSS=Disease Specific Survival. HR: Hazard Ratio. 95% CI: 95% confidence interval.