Table 5.

Multivariate analyses over time

Visit	T1 (baseline)			T2 (4 weeks)			T3 (6 months)			T4 (1 year)			T5 (2 years)
	Factor	β	P	Factor	β	P	Factor	β	P	Factor	β	P	Factor	β	P
Psychomotor speed	BMI	−0.86	0.015	College	53.34	<0.0001	College	28.99	0.005	College	47.43	<0.0001	College	43.99	0.0002
	Stress	−0.79	0.022	High school	57.54	<0.0001	High school	27.05	0.0285	High school	39.59	0.0007	High school	35.93	0.0098
							BMI	−0.79	0.0464	Neoadjuvant no	22.43	0.0151	Neoadjuvant no	39.24	0.0007
							Neoadjuvant no	25.63	0.0232
Reaction time	College	27.68	<0.001	College	19.81	0.0021	College	18.66	0.0016	College	22.30	0.0003	College	22.70	0.0015
	High school	29.13	0.001	High school	21.75	0.0082	High school	17.75	0.0154	High school	24.00	0.0014	High school	23.94	0.0054
	Depression	−1.78	0.030										Depression	−1.56	0.0147
	Stress	0.75	0.025
Complex attention	Black race	−9.68	0.031	Fatigue	−3.34	0.0002	Black race	−16.59	0.0004				HER2+ ER/PR−	18.25	0.0113
	Fatigue	−2.17	0.019										Fatigue	−1.57	0.0339
	Anxiety	−2.32	0.003
	Stress	0.85	0.034
Cognitiv flexibility	Black race	−12.14	0.011	College	22.52	0.0035	Black race	−16.84	0.0007	Black race	−10.73	0.024	College	27.06	0.001
	Fatigue	−2.63	0.008	High school	17.39	0.0768							High school	26.13	0.008
	Anxiety	−1.73	0.035	Fatigue	−2.70	0.0016
	Stress	0.92	0.030
Executive function	Black race	−11.74	0.013	Fatigue	−2.80	0.0014	Black race	−16.99	0.0006	Black race	−11.18	0.0136	Fatigue	−1.53	0.042
	Fatigue	−1.72	0.027							Depression	−1.36	0.0336
Verbal memory	Black race	−11.44	0.005	Black race	−9.32	0.0224	Black race	−17.83	<0.0001	BMI	−0.69	0.012	Black race	−16.12	0.0009
	Fatigue	−1.48	0.025							Black race	−11.57	0.0119	Fatigue	−2.37	0.0148
Visual memory													Stress	0.80	.0196
	Surgery biopsy	−19.69	0.002	Black race	−9.74	0.0157	Black race	−15.85	0.0007	Neoadjuvant no	13.47	0.038	College	21.72	0.0054
	Surgery Lumpectomy	−5.23	0.175							Hormone	9.09	0.026	High School	10.13	0.2671
	Surgery segmental	−11.41	0.009										Neoadjuvant no	21.73	0.008
	Depression	1.14	0.033										Fatigue	−2.27	0.0145
Composite memory													Stress	0.87	0.0119
	Surgery biopsy	−18.95	0.002	Black race	−12.25	0.0013	Black race	−19.94	<0.0001	Black race	−11.98	0.006	Black race	−11.93	0.0146
	Surgery lumpectomy	−8.45	0.023				Anxiety	−1.28	0.0112	Hormone	9.49	0.028	Neoadjuvant no	23.46	0.0070
	Surgery segmental	−13.69	0.002										Fatigue	−3.24	0.0011
													Stress	1.32	0.0006
													Hormone	8.80	0.0361