Fig. 1.
The vicious circle of ‘metabolic memory’ [36]. AGEs advanced glycation end-products, NO nitric oxide, NTF neurotrophic factor, RAGE receptor for advanced glycation end-product. Reproduced with permission from Drzewoski J, Kasznicki J, Trojanowski Z. The role of “metabolic memory” in the natural history of diabetes mellitus. Pol Arch Med Wewn. 2009;119:493–500