Table 2. High-dose chemotherapy regimens.
Regimens | Drugs | Dose | Schedule | Total dose |
---|---|---|---|---|
First HDCT regimens | ||||
CTE | Carboplatin | 500 mg/m2/day | Days -8, -7, and -6 | 1,500 mg/m2 |
Thiotepa | 300 mg/m2/day | Days -5, -4, and -3 | 900 mg/m2 | |
Etoposide | 250 mg/m2/day | Days -5, -4, and -3 | 750 mg/m2 | |
MEC | Melphalan | 35 mg/m2/day | Days -7, -6, -5, and -4 | 140 mg/m2 |
Etoposide | 60 mg/kg/day | Day -3 | 60 mg/kg | |
Carboplatin | 500 mg/m2/day | Days -4, -3, and -2 | 1,500 mg/m2 | |
CEC | Carboplatin | 650 mg/m2/day | Days -7, -6, and -5 | 1,950 mg/m2 |
Etoposide | 650 mg/m2/day | Days -7, -6, and -5 | 1,950 mg/m2 | |
Cyclophosphamide | 1,800 mg/m2/day | Days -4, -3, and -2 | 5,400 mg/m2 | |
Second HDCT regimens | ||||
CM | Cyclophosphamide | 1,500 mg/m2/day | Days -8, -7, -6, and -5 | 6,000 mg/m2 |
Melphalan | 60 mg/m2/day | Days -4, -3, and -2 | 180 mg/m2 | |
TBI-CM | Total body irradiation | 3.33 Gy/day | Days -9, -8, and -7 | 9.99 Gy |
Cyclophosphamide | 1,000 mg/m2/day | Days -6, -5, and -4 | 3,000 mg/m2 | |
Melphalan | 60 mg/m2/day | Days -3, and -2 | 120 mg/m2 |