Table 3. Comparison of In vitro Fertilization– Embryo transfer (IVF-ET) characteristics of control and heterotopic pregnancy patients.
| Variables | IVF-ET patients | P value | |
|---|---|---|---|
| Control n = 84 |
Heterotopic pregnancy n = 40 |
||
| ART method | 0.642‡ | ||
| Fresh non-donor IVF cycles | 72 (85.7%) | 33 (82.5%) | |
| Frozen-thawed cycles | 12 (14.3%) | 7 (17.5%) | |
| Stimulation duration, day | 9.6 ± 1.5 | 7.1 ± 4.9 | 0.017§ |
| Total dose of gonadotropin, IU | 2370.2 ± 728.3 | 2420.2 ± 1205.9 | 0.807§ |
| Serum E2 on hCG day, pg/mL | 3259.9 ± 2410.3 | 2392.1 ± 1312.5 | 0.086§ |
| No. of retrieved oocytes | 7.5 ± 3.3 | 15.9 ± 9.3 | < 0.001§ |
| No. of transferred embryos | 3.1 ± 0.9 | 3.5 ± 0.9 | 0.035§ |
| Fertilization method | < 0.001‡ | ||
| Conventional IVF | 14 (19.4%) | 19 (47.5%) | |
| Partial ICSI | 31 (43.1%) | 0 (0.0%) | |
| All ICSI | 27 (37.5%) | 21 (52.5%) | |
| Cultured day* | 0.420‡ | ||
| Cleavage stage | 65 (77.4%) | 28 (75.7%) | |
| Blastocyst stage | 19 (22.6%) | 9 (24.3%) | |
| OHSS | 4 (4.8%) | 8 (21.1%) | 0.009∥ |
| Serial serum β-hCG, mIU/mL† | |||
| hCG 1st (post OPU #12) | 96.7 ± 86.5 | 83.2 ± 56.6 | 0.387§ |
| hCG 2nd (post OPU #14) | 271.3 ± 209.2 | 277.4 ± 199.9 | 0.881§ |
| hCG 3rd (post OPU #21) | 6803.5 ± 6530.8 | 6049.1 ± 4920.9 | 0.536§ |
Values are expressed as mean ± standard deviation or No. (%).
ICSI, intracytoplasmic sperm insemination; OPU, ovum pick up; OHSS, ovarian hyper-stimulation syndrome.
*3 missing data; †repeated-measures two factor analysis for serial serum β-hCG levels, according to singleton (P = 0.978) and twin (P = 0.715); ‡χ2 test; §t-test; ‖Fisher’s exact test.