Table 4. Analysis of risk factors for clinical outcome (death) using univariate and multivariable logistic regression analyses.
Variables | Univariate analysis (a) | Multivariable analysis (b) | |||||||
---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | P value | OR | 95% CI | P value | ||||
Age | 1.02 | 1.01 | 1.03 | < 0.001 | 1.03 | 1.01 | 1.05 | < 0.001 | |
Sex | 1.05 | 0.79 | 1.38 | 0.747 | |||||
Anion gap | 3.04 | 2.28 | 4.06 | < 0.001 | 2.38 | 1.34 | 4.25 | < 0.001 | |
Creatinine | 5.06 | 3.66 | 7.00 | < 0.001 | 1.66 | 1.10 | 2.51 | 0.02 | |
Field of use class | Herbicide | Reference | |||||||
Insecticide | 0.2 | 0.12 | 0.32 | < 0.001 | |||||
Surfactant | 0.08 | 0 | 0.39 | 0.015 | |||||
Fungicide | 0.1 | 0.02 | 0.5 | 0.026 | |||||
Pesticide class | Bipyridylium | Reference | Reference | ||||||
Glycine Derivative | 0.04 | 0.02 | 0.08 | < 0.001 | 0.02 | 0.00 | 0.06 | < 0.001 | |
Organophosphate | 0.11 | 0.06 | 0.19 | < 0.001 | 0.04 | 0.01 | 0.17 | < 0.001 | |
Phosphinic acid | 0.04 | 0.02 | 0.09 | < 0.001 | 0.04 | 0.01 | 0.20 | < 0.001 | |
Pyrethroid | 0.06 | 0.03 | 0.14 | < 0.001 | 0.01 | 0.00 | 0.09 | < 0.001 | |
Surfactant | 0.03 | 0.01 | 0.17 | 0.001 | 0.06 | 0.01 | 0.53 | 0.01 | |
Chloroacetamide | 0.09 | 0.01 | 0.33 | 0.002 | 0.05 | 0.00 | 2.13 | 0.11 | |
Others | 0.03 | 0.02 | 0.07 | < 0.001 | 0.02 | 0.00 | 0.13 | < 0.001 | |
Ingested volume, mL | 1 | 1 | 1 | 0.1556 | |||||
Time lag, hr* | 1.03 | 1 | 1.06 | 0.048 | |||||
APACHE II score | 1.09 | 1.04 | 1.15 | < 0.001 | |||||
WMSCN score | 1.5 | 1.24 | 1.81 | < 0.001 | 8.87 | 4.37 | 18.03 | < 0.001 | |
ICU admission day | 0.94 | 0.9 | 0.97 | < 0.001 | 4.23 | 2.98 | 6.02 | 0.001 | |
Total admission day | 0.79 | 0.75 | 0.82 | < 0.001 | 0.22 | 0.16 | 0.31 | 0.001 |
Note that age, anion gap, serum creatinine, pesticide class, Workload Management System for Critical Care Nurses (WMSCN) score, and admission day are significant risk factors for death (P < 0.001). Both the number of patients and the death rate were incomparably higher in the herbicide (bipyridylium) category than in the other pesticide categories. Therefore, the death rates in the other pesticide groups are presented in reference to the herbicide (bipyridylium) category.
APACHE II, Acute Physiology and Chronic Health Evaluation II; ICU, intensive care unit.
*time lag: arrival to the hospital after ingestion of pesticide.