Table 2.
Phenotype of ACKRs knockout mice in inflammation and infection models.
| Gene deletion | Phenotype | Reference |
|---|---|---|
| ACKR1 | Reduced neutrophil recruitment in acute inflammation models | (28–30) |
| Renal protection in ischemia or LPS induced acute kidney damage | (31) | |
| Reduced macrophages infiltration in bone fracture model | (32) | |
| Reduced atheroma development in the Apo E KO | (33) | |
| ACKR2 | Severe skin inflammatory reaction similar to psoriasis | (42) |
| Increased granulomatous inflammatory response | (43) | |
| Increased gut and lung inflammation | (44–46) | |
| Increased tissue damage after myocardial infarction | (49) | |
| Increased inflammation-associated miscarriage and allogeneic embryo rejection | (47, 48) | |
| Uncontrolled Mycobacterium tuberculosis infection | (50) | |
| ACKR3a | Exacerbates neointimal hyperplasia | (65) |
| ACKR4 | Excessive Th17 responses | (72) |
aTamoxifen-inducible knockout.