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. 2016 Jun 10;7:217. doi: 10.3389/fimmu.2016.00217

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Copyright © 2016 Chatzipanagiotou, Ioannidis, Trikka-Graphakos, Charalampaki, Sereti, Piccinini, Higgins, Buranda, Durvasula, Hoogesteijn, Tegos and Rivas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mortality rates of perpendicular data segments. Both study I (A) and II (B) displayed mortality rates at least twice higher in the subset located on the right side of the plot than in the left subset (66.6% in both studies vs. 33.3 or 23.1%, in study I or II, respectively). Such differences approached or achieved statistical significance [P = 0.057 (study I) or P ≤ 0.01 (study II), Chi-square test]. When the same data structure was utilized to analyze 20 non-infected, SIRS-negative individuals, the high-mortality subset was not observed (C), even though the scale of the critical axis (BAU) was 1000 times smaller than the scale used in (A,B); i.e., the scale facilitated the detection of any pattern, if present.