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. 2016 Jun 10;7:217. doi: 10.3389/fimmu.2016.00217

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Copyright © 2016 Chatzipanagiotou, Ioannidis, Trikka-Graphakos, Charalampaki, Sereti, Piccinini, Higgins, Buranda, Durvasula, Hoogesteijn, Tegos and Rivas.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Three-dimensional analysis of age data. The age of SIRS+, infected individuals did not explain the mortality rates described in Figure 4. Both study I (A) and II (B) included >65-year-old individuals in the left (low-mortality) subset and <50-year-old individuals in the right (high-mortality) subset. While the median age [large, blue circles (C,D)] was 7–15 years higher in the right subset, any age-based cutoff would result in a large number of errors because the age intervals of survivors and non-survivors overlapped (C,D).