Table 3.
Effects of peptides 18, 24, and 25 on the HIV-1 IN dimerization and multimerization process.
| Compounds | Sequence | IN-IN subunit exchange | IN-multim |
|---|---|---|---|
| aIC50(μM) | cMI50(μM) | ||
| 18 | 31VVAKEIVAH | >100 (100%)b | >100 (100%) |
| 24 | VVAAEIVAH | 32 ± 3 | >100 (100%) |
| 25 | VVAKAIVAH | >100 (100%) | 4.8 ± 0.4 |
| LEDGIN-6 |  |
>100 (100%) | 10 ± 1 |
a
Compound concentration required to inhibit the HIV-1 IN-IN subunit exchange by 50%.
b
Percentage of control measured in the presence of 100 μM concentration.
c
Compound concentration required to inhibit the multimerization increase by 50%.