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Evaluation of the synthesized peptides against HIV-1 and HIV-2 replication in MT-4 cell cultures.
| Peptides | ECa50 (μM) | CCb50 (μM) | |
|---|---|---|---|
| HIV-1 (NL4.3) | HIV-2 (ROD) | MT-4 | |
| Tat-18 | >105 | >105 | 105 |
| Tat-24 | >50 | >50 | >50 |
| Tat-25 | 4.0 ± 0.6 | >21.4 | 21.4 ± 2.0 |
50% Effective concentration, or compound concentration required to inhibit HIV-induced cytopathogenic effect in MT-4 cell culture.
Compound concentration required to reduce by 50% MT-4 cell viability.
