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. 2016 Jun 10;9:43. doi: 10.3389/fnmol.2016.00043

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Copyright © 2016 Pinto, Pedro, Costa and Almeida.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model of presynaptic formation at sites of enhanced K48 polyubiquitination. At axonal domains contacting a synaptic partner, strong accumulation of K48 ubiquitin at nascent sites occurs at the early moments of recruitment of active zone material (Bassoon; 1). Then, formation of a functional presynaptic terminal will be achieved by sustained recruitment of active zone material, as well as synaptic vesicles, which will be properly clustered and assembled (2). Presynaptic formation is dependent on the activity of axonal E1-mediated ubiquitination.