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. 2016 Jun 10;10:58. doi: 10.3389/fncom.2016.00058

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Copyright © 2016 Teplitzky, Zitella, Xiao and Johnson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Modeling axonal activation. Tissue voltage during stimulation was modeled for each stimulation configuration using the finite element method (A). The multi-compartment axon model population superimposed with extracellular potentials derived from the tissue voltage predictions (B). A spatial axonal activation profile, or region of activation (RoA) plot resulting from stimulation at 2.5 mA (C). RoA quantification using regional properties calculated from a closed binary image of the RoA plot (D).