Table 1.
Sociodemographic characteristics and serum hormone levels in the study population
| Macroprolactinemia | Monomeric hyperprolactinemia | Control subjects | |
|---|---|---|---|
| Number of patients | 14 | 14 | 14 |
| Age [years; mean (SD)] | 31 (4) | 30 (5) | 29 (5) |
| Body mass index [kg/m2; mean (SD)] | 25.7 (2.9) | 26.2 (3.7) | 24.9 (3.4) |
| Waist circumference [cm; mean (SD)] | 87 (11) | 88 (13) | 86 (10) |
| Smokers (%)/pack-years of smoking [mean (SD)] | 21/3.13 (0.63) | 21/3.76 (0.73) | 21/4.3 (0.95) |
| Physical activity: total/once a week/several times a week/once a month (%) | 57/14/21/21* | 57/21/14/21* | 79/29/29/21 |
| Primary or vocational/secondary/university education (%) | 36/36/29 | 36/29/36 | 29/36/36 |
| Occupational activity/blue-collar/white-collar/pink-collar workers (%) | 71/21/29/21 | 71/29/21/21 | 79/29/29/21 |
| Number of sexual partners [n; mean (SD)] | 1.7 (0.5)* | 1.6 (0.7)* | 2.2 (0.7) |
| Number of marriages [n; mean (SD)]/duration of marriages [months; mean (SD)] | 1.1 (0.5)/58 (14) | 1.0 (0.5)*/40 (13)* | 1.3 (0.5)/55 (16) |
| Number of deliveries [n; mean (SD)]/number of abortions [n; mean (SD)] | 1.0 (0.5)/0.2(0.4) | 0.7 (0.6)*/0.3(0.4) | 1.2 (0.5)/0.2 (0.4) |
| Stress exposure [%, mean (SD)] | 79 | 71 | 71 |
| Systolic blood pressure [mm Hg; mean (SD)] | 117 (9) | 121 (11) | 115 (10) |
| Diastolic blood pressure [mm Hg; mean (SD)] | 74 (5) | 76 (5) | 73 (6) |
| Prolactin before polyethylene glycol precipitation [ng/mL]b | 65 (15)** | 59 (13)** | 12 (4) |
| Prolactin after polyethylene glycol precipitation [ng/mL]c | 11 (4)*** | 51 (12) | 10 (3)*** |
| Macroprolactin (%)a,d | 83 (10)**,*** | 14 (6) | 17 (8) |
| Testosterone [ng/dL; mean (SD)] | 28 (8) | 24 (9) | 30 (8) |
| 17β-estradiol [pg/mL; mean (SD)] | 64 (16) | 56 (14) | 68 (18) |
All means and standard deviations (SD) represent unadjusted values
* p < 0.05, ** p < 0.001 versus control women; *** p < 0.001 versus women with monomeric hyperprolactinemia
a[1 − (serum prolactin after polyethylene glycol precipitation/serum prolactin before polyethylene glycol precipitation)] × 100
b F[2,39] = 38.6, p < 0.001
c F[2,39] = 41.3, p < 0.001
d F[2,39] = 46.2, p < 0.001