Table 1.

The broad effects on commonly considered risk factors of differing classes of new diabetes agents

Risk factor	DPP-4 inhibitors	GLP-1 receptor agonists	SGLT2 inhibitors
Hypoglycaemia risk	Low	Low	Low
Weight	Neutral	Reduced	Reduced
Blood pressure	Neutral	Lower	Lower
Lipids	Neutral	HDL-cholesterol ↑ / triacylglycerols ↓	Mixed (LDL-cholesterol ↑ / HDL-cholesterol ↑ / triacylglycerols ↓)
Other miscellaneous effects of potential relevance	Increase in heart failure in some trials	Heart rate ↑ variably among different GLP-1 receptor agonists	Genital infections