Figure 3.

Growth dynamics and chemosensitivity of PPCLs. A and B:In vivo (A) and in vitro (B) growth curves of PPCLs through 6 and 40 days, respectively. The growth rate of PPCLs and corresponding tumors were evaluated. Mean tumor volume is presented at each time point. C: Dose-dependent response to gemcitabine treatment of PPCLs, at concentration of 0, 3, 10, 30, 100, 300, and 1000 nmol/L. The IC₅₀ of each line was measured. Viability at each concentration is presented. D: The doubling time, in vitro and in vivo growth rates, and IC₅₀ for each PPCL are summarized. Data are expressed as means ± SEM. n = 3 (A and B); n = 6 (C). All experiments were performed in triplicate. IC₅₀, half maximal inhibitory concentration; PPCL, primary pancreatic cancer cell line.