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. 2016 Jun;186(6):1427–1434. doi: 10.1016/j.ajpath.2016.01.020

Figure 3.

Figure 3

Genome-wide mapping of the nestin gene using hMeDIP-seq for 5-hydroxymethylcytosine (5-hmC) in human benign nevi and melanomas, as well as human melanoma cell lines with ten-eleven translocation methylcytosine dioxygenase (TET2) overexpression (A2058 TET2-OE) and A2058 control cells. The distribution of 5-hmC revealed more abundant binding in the nestin 3′ untranslated region (red box) in nevi and A2058 TET2-OE melanoma cells compared to those of melanomas and control A2058 melanoma cells, respectively. CCDS, consensus CDS; hg, human genome; NES, nestin gene; UCSC, University of California at Santa Cruz.