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. 2016 Jun;186(6):1688–1700. doi: 10.1016/j.ajpath.2016.01.023

Figure 2.

Figure 2

Angiotensin-converting enzyme (ACE)-2 overexpression decreases retinal acellular capillaries. A: Prevention cohort; representative images of retinal vasculature after trypsin digestion showing acellular capillaries (arrowheads) in green fluorescent protein (GFP)-chimeric, streptozotocin (STZ)–diabetic, and vehicle (Veh)–control (Con) mouse retinas. B: Prevention cohort; quantification of retinal acellular capillaries. C: Reversal cohort; representative images of retinal vasculature after trypsin digestion showing acellular capillaries (arrowheads) in GFP-chimeric, STZ-diabetic, and Veh-Con mouse retinas. D: Reversal cohort; quantification of retinal acellular capillaries. Data are expressed as means ± SEM. ∗P < 0.05 versus STZ-Con; †P < 0.05 versus respective nondiabetic control. Scale bar = 50 μm.