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. 2016 Jun;186(6):1688–1700. doi: 10.1016/j.ajpath.2016.01.023

Figure 4.

Figure 4

Angiotensin-converting enzyme (ACE)-2 overexpression prevents diabetes-induced increase of glial fibrillary acidic protein (GFAP) expression in the prevention study. A: Prevention cohort; representative immunofluorescence images showing GFAP-positive astrocytes (red). B: Prevention cohort; percent area of GFAP staining in green fluorescent protein (GFP)–chimeric, streptozotocin (STZ)–diabetic, and vehicle (Veh)–control (Con) mouse retinas. C: Reversal cohort; representative immunofluorescence images showing GFAP-positive astrocytes (red). D: Reversal cohort; percent area of GFAP staining in GFP-chimeric, STZ-diabetic, and Veh-Con mouse retinas. Data are expressed as percent area ± SEM. ∗P < 0.05 versus STZ-Con. Scale bar = 100 μm. GCL, ganglion cell layer; INL, inner nuclear layer; ONL, outer nuclear layer.