Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Apr 27;59:1430–1436. doi: 10.1007/s00125-016-3964-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2016

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

PMC Copyright notice

Fig. 2 — MgATP inhibition of K_ATP channels is reduced by the Kir6.2-G324R mutation. (a) Representative currents recorded at −60 mV from inside-out patches excised from oocytes expressing WT or mutant K_ATP channels. The dashed line indicates the zero current level. MgATP (10 μmol/l) was applied as indicated. (b, c) Relationship between K_ATP current and MgATP concentration for WT (black squares), homG324R (grey filled squares; b) and hetG324R (grey empty squares; c) channels. Current in the presence of nucleotide (I) is expressed as a fraction of that in its absence (I_C). The curves are the best fit to the Hill equation. ***p < 0.001 compared with WT (t test)