Table 1. Relationship between PKM2 expression and clinicopathological characteristics of GBC.
| Variable | No. of cases | PKM2-low expression N (%) | PKM2-high expression N (%) | P-value |
|---|---|---|---|---|
| Age | Mean | 65 (range: 39–87) | ||
| <60 | 20 | 9 (45.0) | 11 (55.0) | 0.574 |
| ≥60 | 50 | 22 (44.0) | 28 (56.0) | |
| Sex | ||||
| Male | 18 | 5 (27.8) | 13 (72.2) | 0.086 |
| Female | 52 | 26 (50) | 26 (50) | |
| Histological Grade | ||||
| Well-differentiated | 6 | 2 (33.3) | 4 (66.7) | 0.851 |
| Moderately differentiated | 51 | 23 (45.1) | 28 (54.9) | |
| Poorly differentiated | 13 | 6 (46.2) | 7 (53.8) | |
| Neurovascular Infiltration | ||||
| Absent | 34 | 18 (52.9) | 16 (47.1) | 0.126 |
| Present | 36 | 13 (36.1) | 23 (63.9) | |
| Pathologic T stage | ||||
| pT1 | 13 | 10 (76.9) | 3 (23.1) | 0.0003 |
| pT2 | 17 | 10 (58.8) | 7 (41.2) | |
| pT3 | 20 | 7 (35.0) | 13 (65.0) | |
| pT4 | 20 | 4 (20.0) | 16 (80.0) | |
| Lymph node metastasis | ||||
| N0 | 37 | 20 (54.1) | 17 (45.9) | 0.041 |
| N1 | 24 | 9 (37.5) | 15 (62.5) | |
| N2 | 9 | 2 (22.2) | 7 (77.8) | |
| Distant metastasis | ||||
| Not present at operation | 47 | 20 (54.1) | 21 (44.7) | 0.007 |
| Present at operation | 23 | 9 (37.5) | 18 (78.3) | |
| TNM stage | ||||
| Stage I | 8 | 7 (87.5) | 1 (12.5) | 0.003 |
| Stage II | 14 | 9 (64.3) | 5 (35.7) | |
| Stage III | 17 | 7 (41.2) | 10 (58.8) | |
| Stage IV | 31 | 8 (25.8) | 23 (74.2) | |
Note: The clinicopathological information of 70 GBC patients from Xinhua Hospital who enrolled in the study were used for statistical analysis of the association between PKM2 expression and age, sex, or histological grade.