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. Author manuscript; available in PMC: 2017 Jun 6.
Published in final edited form as: Dev Cell. 2016 Jun 6;37(5):444–457. doi: 10.1016/j.devcel.2016.05.004

Figure7. FANCI and Blm also facilitate papillar DSB survival.

Figure7

A.Avg. adult papillar cell number/animal for WT and indicated FANCD2 network mutants +/−IR. From N=7-25 animals/condition, multiple replicates. *=significant change +/−IR compared to WT (Methods). Yellow bars=mean. B.Avg. adult papillar cell number/animal for WT and indicated mutants +/−I-Cre. From N=9-11 animals/condition, multiple replicates. *= significant change +/−I-Cre compared to WT (Methods). Yellow bars=mean. C.fanci RNAi#1 adult rectum after IR. D.fancm adult rectum after I-Cre. E.fanci RNAi#1 adult rectum after I-Cre. F.blm RNAi#1 adult rectum after I-Cre. Papillae false-colored green, DNA in purple in C-F. G.Number PH3+ micronuclei +/− I-Cre in WT vs. fanciRNAi#1 and fanciRNAi#2. Yellow bars= mean. From N=9-27 animals/condition, multiple replicates. H,I.Survival of fanci RNAi#1 adults without (blue) or with (red) I-Cre expression, plotted over time for the indicated diet conditions. Bars= standard error. Each genotype/condition represents 3 replicates with 10 animals/replicate. DAPI=DNA in all images. White scale bar=50μm, yellow scale bar=5μm.