Figure 3. p38 MAPK knockdown increases dendritic spine number on hippocampal CA1 pyramidal cells.

(A) WT and p38^KI/+ mice were subjected to hypertension surgery at 9 weeks of age. Four wks post-surgery, western blotting was performed on the hippocampal lysates.Right bar graph shows quantification of p38 MAPK phosphorylation in hippocampus, n = 3 mice per experimental group. (B) Representative Golgi stain image. Right bar graph shows quantification of dendritic spine density, n = 3, and five neurons per mouse were analyzed. Data are presented as mean ± SEM. ***p < 0.001, **p < 0.01, ^#p < 0.05 by one-way ANOVA with Bonferroni post-test.