Table 3. Performance comparison of predictor with different LSA on PDNA-62 by five-fold cross-validation.

Methods	ACC (%)	MCC	SN (%)	SP (%)	ST (%)	AUC
Botha	84.40	0.563	84.94	84.32	84.63	0.917
Both _LSA _Allb	84.28	0.550	82.63	84.58	83.61	0.908
Both _LSA _PSSMc	85.11	0.582	86.27	84.91	85.59	0.928

^aThe predictor using both the sequence and spatial contexts and not applying LSA.

^bThe predictor using both the sequence and spatial contexts and applying LSA on the whole feature space.

^cThe predictor using both the sequence and the spatial context and applying LSA on the sub feature space spanned by the PSSM features, that is, our PDNAsite.