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. 2016 Jun 10;14:169. doi: 10.1186/s12967-016-0933-6

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Gene expression levels of the Tgfb1/TGFB1 cascade in human OP lesions, compared to controls. TGFB1/Tgfb1, CXCL12/Cxcl12, TIMP1/Timp1, TIMP2/Timp2, COL3A1/Col3a1 and MMP2/Mmp2 show an OP lesion-specific overexpression in both human and murine lungs. In contrast, BMP4 and BMPR1B were upregulated in human OP lesions, compared to controls, while in murine lungs both genes were downregulated. There was no significant difference in the expression level of IL6/Il6. Ctrl.—control(s)