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. 2016 Jun 10;14:43. doi: 10.1186/s12951-016-0200-2

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — PapMV nanoparticles protect mice from an influenza virus challenge from day 10 post-immunization. Vaccinated mice were challenged with a lethal dose of influenza virus [A/WSN/33 (H1N1)] at different time points; 5 (a), 7 (b) 10 (c), (d) 14 days post-immunization. Mice were euthanized when their weight was equal to, or lower than, 20 % of their initial weight. Kaplan–Meier survival curves were analysed by the log rank test (**p < 0.01)