Table 2.

Romiplostim therapy in five dogs with primary and secondary immune thrombocytopenia: Dosage, response and outcome

Dog	Current therapy at the commencement of romiplostim	Platelets count x103/μl	Romiplostim μg/kg (initial dose)	Response		Maintenance therapy	Outcome
				Day	Platelets count x103/μl
1	pred 0.5 mg/kg twice daily MMF 5 mg/kg twice daily	19	5	673	13226	2.3 μg romi	CR > 10 mon
2	pred 0.6 mg/kg twice daily	57	3	383 5131	8222 15332	now 2 μg/kg romi 0.1 mg/kg pred every other daya	CR > 3 mon
3	pred 0.6 mg/kg twice daily MMF 5 mg/kg twice daily	25	5	4710	58 189 217	2.5 μg	ITP CR but euthanized due to AIHA after 2.5 mon
4	pred 0.5 mg/kg twice daily	123	4.5	3178	5213	3.4	CR > 5 mon
5	a) pred 0.4 mg/kg once daily, doxycycline b) 2 months later: pred 0.5 mg/kg, amoxicillin	a) 4 b) 1	a) 5.3 b) 13	a) No response b) 4 11 15	7 3 115		b) Lost for follow-up

Romi romiplostim, pred prednisolone, MMF mycofenolate mofetil, CR complete remission (platelet counts > 200 × 10³/μl), ITP immune thrombocytopenia, AIHA autoimmune hemolytic anemia, mon months

^adue to autoimmune hemolysis