Figure 6.

Motor pulling cargo on an elastic linker. The motor can be trapped in a flashing periodic potential (here, two realizations shifted by a half of a spatial period are shown). These fluctuations are caused and driven by conformational fluctuations of the motor protein. The pertinent, minimalist, two-state cyclic model of the corresponding biochemical enzymatic cycle is shown on the right. Mechanical motion, induced by cycling, exerts a back influence on cycling via spatially dependent transition rates. This can cause anomalously slow enzyme kinetics that cannot be characterized by a turnover rate in viscoelastic environments [85].