Table II.
History of laparoscopically confirmed endometriosis and risk of incident infertility among married women in Nurses' Health Study II from 1989 to 2005.
| Laparoscopically confirmed endometriosis | No | Yes | P-value |
|---|---|---|---|
| Cases, N | 4429 | 183 | |
| Person-years | 353 490 | 8730 | |
| Age-adjusted HR (95% CI) | 1.00 (ref) | 2.12 (1.76–2.56) | <0.0001 |
| Multivariate-adjusted HRa (95% CI) | 1.00 (ref) | 2.11 (1.74–2.54) | <0.0001 |
| Multivariate-adjusted HRb (95% CI) | 1.00 (ref) | 1.78 (1.48–2.15) | <0.0001 |
HR, hazard ratio; CI, confidence interval.
aAdjusted for age (months), age interaction term, questionnaire cycle, age at menarche, menstrual cycle length between ages 18 and 22 years, current BMI, total physical activity, smoking status, cumulatively updated average AHEI diet score.
bAdditionally adjusted the multivariate model for parity (number of children).