Table III.
Laparoscopically confirmed endometriosis | Primary infertility |
Secondary infertility |
P-het | ||||
---|---|---|---|---|---|---|---|
No | Yes | P-value | No | Yes | P-value | ||
Cases, n | 2132 | 101 | 2297 | 82 | |||
Person-years | 42 606 | 1409 | 310 883 | 7321 | |||
Age-adjusted HR (95% CI) | 1.00 (ref) | 1.81 (1.41–2.33) | <0.0001 | 1.00 (ref) | 1.85 (1.38–2.49) | <0.0001 | |
Multivariate-adjusted HRb (95% CI) | 1.00 (ref) | 1.79 (1.39–2.30) | <0.0001 | 1.00 (ref) | 1.73 (1.29–2.33) | 0.0003 | 0.54 |
Laparoscopically confirmed endometriosis | Age <35 years |
Age 35–39 years |
P-het | ||||
No | Yes | P-value | No | Yes | P-value | ||
Cases, n | 2896 | 114 | 1533 | 69 | |||
Person-years | 156 338 | 3038 | 197 151 | 5691 | |||
Age-adjusted HR (95% CI) | 1.00 (ref) | 2.12 (1.76–2.56) | <0.0001 | 1.00 (ref) | 1.56 (1.23–1.99) | 0.0003 | |
Multivariate-adjusted HRa (95% CI) | 1.00 (ref) | 2.11 (1.74–2.54) | <0.0001 | 1.00 (ref) | 1.57 (1.23–2.00) | 0.0003 | |
Multivariate-adjusted HRb (95% CI) | 1.00 (ref) | 1.77 (1.46–2.14) | <0.0001 | 1.00 (ref) | 1.20 (0.94–1.53) | 0.14 | 0.008 |
Laparoscopically confirmed endometriosis | BMI <25 kg/m2 |
BMI 25+ kg/m2 |
P-het | ||||
No | Yes | P-value | No | Yes | P-value | ||
Cases, n | 3092 | 145 | 1326 | 37 | |||
Person-years | 239 447 | 5626 | 113 012 | 3068 | |||
Age-adjusted HR (95% CI) | 1.00 (ref) | 2.44 (1.98–3.00) | <0.0001 | 1.00 (ref) | 1.33 (0.85–2.09) | 0.21 | |
Multivariate-adjusted HRa (95% CI) | 1.00 (ref) | 2.46 (1.99–3.03) | <0.0001 | 1.00 (ref) | 1.28 (0.82–2.00) | 0.28 | |
Multivariate-adjusted HRb (95% CI) | 1.00 (ref) | 1.96 (1.59–2.42) | <0.0001 | 1.00 (ref) | 1.30 (0.83–2.05) | 0.25 | 0.02 |
aAdjusted for age (months), age interaction term (except for age stratified analysis), questionnaire cycle, age at menarche, menstrual cycle length between ages 18 and 22 years, current BMI, total physical activity, smoking status, cumulatively updated average AHEI diet score.
bAdditionally adjusted the multivariate model for parity (number of children).