Table IV.
Laparoscopically confirmed endometriosis | Total population |
Primary infertility |
Secondary infertility |
P-het | ||||||
---|---|---|---|---|---|---|---|---|---|---|
No | Yes | P-value | No | Yes | P-value | No | Yes | P-value | ||
Cases, n | 4206 | 406 | 1968 | 265 | 2238 | 141 | ||||
Person-years | 351 318 | 10 901 | 42 135 | 1880 | 309 183 | 9021 | ||||
Age-adjusted HR (95% CI) | 1.00 (ref) | 4.02 (3.55–4.55) | <0.0001 | 1.00 (ref) | 3.70 (3.17–4.33) | <0.0001 | 1.00 (ref) | 2.65 (2.12–3.32) | <0.0001 | |
Multivariate-adjusted HRa (95% CI) | 1.00 (ref) | 3.23 (2.85–3.67) | <0.0001 | 1.00 (ref) | 3.68 (3.15–4.31) | <0.0001 | 1.00 (ref) | 2.57 (2.06–3.22) | <0.0001 | 0.09 |
Laparoscopically confirmed endometriosis | Age <35 years |
Age 35–39 years |
P-het | |||||||
No | Yes | P-value | No | Yes | P-value | |||||
Cases, n | 2731 | 279 | 1475 | 127 | ||||||
Person-years | 155 399 | 3978 | 195 917 | 6923 | ||||||
Age-adjusted HR (95% CI) | 1.00 (ref) | 4.02 (3.55–4.55) | <0.0001 | 1.00 (ref) | 2.44 (2.03–2.92) | <0.0001 | ||||
Multivariate-adjusted HRa (95% CI) | 1.00 (ref) | 3.21 (2.83–3.64) | <0.0001 | 1.00 (ref) | 1.83 (1.52–2.20) | <0.0001 | <0.001 | |||
Laparoscopically confirmed endometriosis | BMI <25 kg/m2 |
BMI 25+ kg/m2 |
P-het | |||||||
No | Yes | P-value | No | Yes | P-value | |||||
Cases, n | 2922 | 315 | 1273 | 90 | ||||||
Person-years | 237 944 | 7127 | 112 358 | 3722 | ||||||
Age-adjusted HR (95% CI) | 1.00 (ref) | 4.46 (3.87–5.14) | <0.0001 | 1.00 (ref) | 2.95 (2.25–3.87) | <0.0001 | ||||
Multivariate-adjusted HRa (95% CI) | 1.00 (ref) | 3.42 (2.96–3.95) | <0.0001 | 1.00 (ref) | 2.72 (2.06–3.59) | <0.0001 | 0.05 |
aAdjusted for age (months), age interaction term (except for age stratified analysis), questionnaire cycle, age at menarche, menstrual cycle length between ages 18 and 22 years, current BMI, total physical activity, smoking status, cumulatively updated average AHEI diet score, parity (number of children).