Table 3.

Sensitivity analyses via the E/e’ level

Analytic strategies	Marker of diastolic dysfunction
	E/e'	OR [95% CI]
Ordinal logistic regression models (continuous scale of mRS score as a dependent variable)
mRS score at 3 months	<8	Reference
	8-15	1.00 [0.86-1.17]
	≥15	1.58 [1.24-2.00]
mRS score at 1 year	<8	Reference
	8-15	1.00 [0.84-1.18]
	≥15	1.58 [1.22-2.04]
Subjects with preserved ejection fraction (N=2,751)
Functional dependency or death at 3 months (mRS score 2-6)	<8	Reference
	8-15	0.98 [0.80-1.20]
	≥15	1.69 [1.23-2.32]
Composite vascular events at 3 months	<8	Reference
	8-15	1.16 [0.82-1.65]
	≥15	1.33 [0.80-2.21]
Functional dependency or death at 1 year (mRS score 2-6)	<8	Reference
	8-15	0.94 [0.75-1.17]
	≥15	1.39 [0.99-1.97]
Composite vascular events at 1 year	<8	Reference
	8-15	1.16 [0.84-1.59]
	≥15	1.68 [1.08-2.60]
Subjects without atrial fibrillation (N=2,394)
Functional dependency or death at 3 months (mRS score 2-6)	<8	Reference
	8-15	0.94 [0.76-1.17]
	≥15	1.77 [1.26-2.50]
Composite vascular events at 3 months	<8	Reference
	8-15	1.16 [0.80-1.69]
	≥15	1.36 [0.78-2.39]
Functional dependency or death at 1 year (mRS score 2-6)	<8	Reference
	8-15	0.89 [0.70-1.12]
	≥15	1.37 [0.95-1.98]
Composite vascular events at 1 year	<8	Reference
	8-15	1.10 [0.79-1.54]
	≥15	1.88 [1.17-3.00]

Multivariable models were adjusted for age, sex, hyperacute recanalization treatment, mechanism of ischemic stroke, hypertension, diabetes, hyperlipidemia, habitual smoking, atrial fibrillation, hemoglobin, initial random glucose, total cholesterol, NIHSS at initial presentation, and mRS score before the index stroke.

LV, left ventricle; OR, odds ratio; CI, confidence interval; mRS, modified Rankin Scale; composite vascular events include recurrent stroke, myocardial infarction and vascular death after the index stroke.