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Enantio- and diastereoselective bifunctional thiourea 12 organocatalysed Michael addition. (a) CO(OMe)2, LHMDS, THF, −78 °C to rt, 83%; (b) 20 mol % 12, toluene, −20 °C, 24 h, 95:5 dr (13:14), 90:10 er for 13, 99% yield; (c) butylamine, aq formaldehyde, MeOH, reflux, 1 h, 63%.
