Table 2.
Metabolites reported to date from myxobacteria grouped into the suborder Nannocystineae and their bioactivities.
| genus | classification according to salt requirements for growth | metabolites | metabolite [No] bioactivity |
| Nannocystis | terrestrial | nannocystin A (10) |
10 antiproliferative activity, MDA-MB231 and its related drug resistant MDA-A1 (IC50 = 6.5 and 12 nM respectively), HCT116 (IC50 = 1.2 nM) and PC3 (IC50 = 1.0 nM) |
| halotolerant | phenylnannolone A, B, C (11–13), pyrronazol A, A2, B, C1, C2 (14–18), nannozinone A, B (21, 22), nannochelin A (23) |
11 reversing drug-resistance of tumor cells 21 Mycobacterium diernhoferi, Candida albicans, Mucor hiemalis, MICs: 33.3 μg mL−1 in each case 22 cytotoxicity, SKOV-3 IC50 = 2.4 μM, KB3-1 IC50 = 5.3 μM and A431 IC50 = 8.45 μM 23 cytotoxicity, HUVEC and KB3-1 IC50 = 50 nM |
|
| Haliangium | moderately halophilic | haliangicin (24) haliamide (25) |
24 Aspergillus niger, MIC: 12.5 μg mL−1, Phytophthora capsici, MIC: 0.4 μg mL−1; 25 Cytotoxicity, HeLa-S3, IC50 12 μM |
| Enhygromyxa | halophilic | salimabromide (26) enhygrolide A, B (27, 28) salimyxin A, B (29, 30) |
26, 27, 30 Arthrobacter crystallopoietes, MICs: 16, 8 and 4 μg mL−1, respectively |
| Myxobacterium SMH-27-4 (Paraliomyxa) |
slightly halophilic | miuraenamide A–F (31–36) |
31 Trichophyton mentagrophytes, MIC: 12.5 μg mL−1 |
| Plesiocystis | halophilic | no metabolites described | – |
| Pseudenhygro-myxa | halotolerant | no metabolites described | – |