Table 3.
Summary of prebiotic RCTs in premature infants
| Author Year | Country | Prebiotic (composition) | Brand (Company) | Population | Dose × duration | Number enrolled | NEC cases Stage 2, 3 | Culture + sepsis cases | Deaths | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Preb | Cont | Preb | Cont | Preb | Cont | Preb | Cont | ||||||
| Dilli 201561 | Turkey | Inulin | Maflor (Mamsel) | BW < 1500g + GA < 32w | 900mg/d until discharge | 100 | 100* | 12 | 18* | 10 | 13* | 2 | 12* |
| Armanian 2014124 | Iran | scGOS:lcF OS(9:1) | NR (Nutricia MMP) | BW < 1500g + GA < 34w | varied with feeding volume | 25 | 50 | 1 | 11 | 4 | 17 | 1 | 1 |
| Riskin 2010125 | Israel | 1% lactulose | Laevo lac, (Fresenius Kabi) | GA 23-34w | 1g/100 ml each feed until discharge | 15 | 13 | 1 | 2 | 2 | 4 | 0 | 1 |
| Modi 2010126 | UK | scGOS:lcF OS (9:1) | NR (Danone) | GA < 33w | 0.8g/10 ml(of formula feedings only) | 73 | 81 | 2 | 1 | 9 | 10 | 2 | 1 |
| Westerbeek 2010127 | Netherlands | 80% scGOS/lcF OS + 20% AOS | NR | BW < 1500g and/or GA < 32w | 1.5g/kg/d × 28d | 55 | 58 | 10 | 6 | 32 | 48 | 2 | 3 |
| total | 268 | 302 | 26 | 38 | 57 | 92 | 7 | 18 | |||||
| % of reported | 100 | 100 | 9.70 | 12.58 | 21.27 | 30.46 | 2.61 | 5.96 | |||||
NR: not reported, BW: birth weight, GA: gestational age, g: grams, w: weeks, d: days
scGOS: short-chain galacto-oligosaccharides, lcFOS: long-chain fructo-oligosaccharides, AOS: acidic oligosaccharides
*
Same control group as reported in Table 1