Table 4.
Summary of synbiotic RCTs in premature infants
| Author Year | Country | Synbiotic | Brand (Company) | Population | Dose × duration | Number enrolled | NEC cases Stage 2, 3 | Culture + sepsis cases | Deaths | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Synb | Cont | Synb | Cont | Synb | Cont | Synb | Cont | ||||||
| Dilli 201561 | Turk | Inulin + B lactis | Maflor (Mamsel) | BW < 1500g + GA < 32w | inulin 900 mg + 5e9/d × 8w | 100 | 100* | 4 | 18* | 8 | 13* | 3 | 12* |
| Nandhini 2015130 | India | Inulin + L acidophilus + LGG + L casei + L plantarum + L bulgaricus + B infantis + B breve + B longum | Prepro HS (Fourrts) | BW > 1000g + GA 28-34w | 100 mg/d + 7×109 4×109 3×109 3×109 3×109 3×109 3×109 4×109 BID × 7d | 108 | 110 | 0 | 3 | 4 | 4 | 10 | 9 |
| Underwood 2009131 | USA | Inulin + LGG | ProBio Plus (UAS) | BW 750-2000g + GA < 35w | 5e8 BID × 28d or until discharge | 30 | 29 | 1 | 1 | 6 | 5 | 0 | 0 |
| Inulin + L acidophilus + B longum + B bifidum + B infantis | 31 | 1 | 2 | 0 | |||||||||
| total | 269 | 239 | 6 | 22 | 20 | 22 | 13 | 21 | |||||
| % of reported | 100 | 100 | 2.23 | 9.20 | 7.43 | 9.20 | 4.83 | 8.79 | |||||
LGG: L rhamnosus (GG), NR: not reported, BW: birth weight, GA: gestational age, g: grams, w: weeks, d: days
5e9: 5×109 organisms
*
Same control group as reported in Table 1