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. Author manuscript; available in PMC: 2017 Apr 1.

Published in final edited form as: Clin Ther. 2016 Feb 9;38(4):716–732. doi: 10.1016/j.clinthera.2016.01.006

Table 5.

Summary of lactoferrin RCTs in premature infants

Author Year	Country	Lactoferrin	Brand (Company)	Population	Dose × duration	Number enrolled		NEC cases Stage 2, 3		Culture + sepsis cases		Deaths
Author Year	Country	Lactoferrin	Brand (Company)	Population	Dose × duration	Lact	Cont	Lact	Cont	Lact	Cont	Lact	Cont
Kaur 2015¹³⁶	India	bLF	apolactoferrin (NR)	BW < 2000g	varied with BW × 28d	63	67	NR	NR	2	9	0	5
Ochoa 2015¹³⁷	Peru	bLF	NR (Tatua)	BW < 2500g	200mg/kg/d devided 3 doses × 28d	95	95	NR	NR	4	4	7	3
Akin 2014¹³⁸	Turk	bLF	LF100 (Dicofarm)	BW < 1500g + GA < 32w	200mg/d until discharge	22	25	0	5	4	8	0	1
Manzoni 2014¹³⁹	Italy	bLF	LF100 (Dicofarm)	BW < 1500g	100mg/d × 30d BW > 1000g × 45d BW < 1000g	247	258	5	14	NR	NR	5	18
Manzoni 2014¹³⁹	Italy	bLF + LGG	Dicoflor 60 (Dicofarm)	BW < 1500g	100mg/d + 6e9/d	238	258	0	14	NR	NR	9	18
Sherman 2013^*¹⁴⁰	USA	talactoferrin	NR	750-1500g	150 mg/kg BID	60	60	NR	NR	4	4	1	1
				total		725	505	5	19	14	25	22	28
				% of reported		100	100	0.99	6.71	5.83	10.12	3.03	5.54

NR: not reported, BW: birth weight, GA: gestational age, g: grams, w: weeks, d: days

bLF: bovine lactoferrin , LGG: L rhamnosus (GG)

^*

Abstract only