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. 2016 May 17;49(1):123–132. doi: 10.3892/ijo.2016.3527

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Copyright: © Qi et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Inhibition of cell invasion and migration induced by pVAX-MP:lip in vitro. (A) Wound healing analysis of migration. The cell motility was enhanced in the VEGFD-SK group. However, the cell motility was decreased in the pVAX-MP:lip group: the wound widths in the pVAX-MP:lip group was wider than in VEGFD-SK or pVAX:lip group. (B) Transwell assay was performed to evaluate cell invasion. Migratory capacity was increased in VEGFD-SK cells (x100). The number of invading cells in the VEGFD-SK group was increased compared with other groups. While the numbers of invading cells in the pVAX-MP:lip groups were obviously lower than in the pVAX:lip group (x100). (C) VEGFD-SK cells had much high migration ability, but pVAX-MP:lip group had the lowest migration tendency in the wound healing assay (^*P<0.05 WT-SK group versus VEGFD-SK group; ^**P<0.05 pVAX-lip group versus pVAX:lip group).