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. 2016 Apr 25;49(1):89–98. doi: 10.3892/ijo.2016.3496

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Copyright: © Yamashita et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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The expression of CD13 before and after treatment with anticancer drugs, with/without ubenimex. (A) The expression of CD13 was 3.5±0.5% in HuH7 cells and 3.9±0.4% in PLC/PRF/5 cells. (B) The expression of CD13 increased after 72 h of exposure to 5-FU, CDDP, DXR and SOR in HuH7 cells and PLC/PRF/5 cells; (P<0.05). (C) When ubenimex (Ube) was combined with each anticancer drug, the expression of CD13 decreased compared to the anticancer drug alone in HuH7 cells and PLC/PRF/5 cells (P<0.05).