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. 2016 Apr 25;49(1):89–98. doi: 10.3892/ijo.2016.3496

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Copyright: © Yamashita et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Ubenimex regulated cell cycle in cooperation with anticancer drugs. Compared to controls without drug (white), Ube (light gray) decreased the percentage of cells in the G0/G1 cell cycle phase. At 48 h, HuH7 cells and PLC/PRF/5 cells treated with 5-FU, CDDP, DXR and SOR combined with Ube (black) showed significantly smaller percentages of cells in the G0/G1 phase and larger percentages of cells in the S/G2/M phases, compared to the percentages observed with anticancer drugs alone (dark gray), (mean ± SD, from three different replicates) ^*P<0.05.