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Ubenimex potentiated apoptosis when combined with 5-FU, CDDP and DXR, compared to the effects of each anticancer drug alone. Flow cytometric analyses with Annexin V assays showed that the rate of apoptosis was significantly higher in HuH7 cells and PLC/PRF/5 cells treated with 5-FU, CDDP and DXR combined with ubenimex (Ube), compared to those treated with anticancer drug alone. (A) The percentage of apoptotic cells detected (mean ± SD, from three different replicates) (B), *P<0.05.
