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. Author manuscript; available in PMC: 2016 Jul 6.
Published in final edited form as: Sci Transl Med. 2016 Jan 6;8(320):320ra2. doi: 10.1126/scitranslmed.aad1863

Table 2. Stages in the HIV infection and care continuum.

Infection/care stage of transmitter Definition
Undiagnosed Transmission intervals whose midpoint is before diagnosis:
    Confirmed recent infection at diagnosis     All transmission intervals of transmitters that were in laboratory confirmed recent infection at time of diagnosis.
    Estimated to be in recent infection     Considering transmitters that had no evidence for recent infection at time of diagnosis, all transmission intervals whose midpoint is less than 12 months after the estimated infection date.
    Estimated to be in chronic infection     Considering transmitters that had no evidence for recent infection at time of diagnosis, all transmission intervals whose midpoint is more than 12 months after the estimated infection date.
Diagnosed Transmission intervals whose midpoint is after diagnosis and before ART start (only of transmitters that are in contact with care services):
     Diagnosed < 3mo, Recent infection at diagnosis      Considering potential or probable transmitters that were in laboratory confirmed recent infection at time of diagnosis, all transmission intervals whose midpoint is within the first three months after diagnosis.
     No CD4 measured      No available CD4 count since diagnosis up to the midpoint of the interval.
     CD4 > 500      CD4 counts remained above 500 cells/ml between the first CD4 count up to the midpoint of the interval.
     CD4 in [350-500]      CD4 counts decreased to 350-500 cells/ml between the first CD4 count up to the midpoint of the interval.
     CD4 < 350      CD4 counts decreased to below 350 cells/ml between the first CD4 count up to the midpoint of the interval.
ART initiated Transmission intervals whose midpoint is after ART start (only of transmitters that are in contact with care services):
Before first viral suppression      No first viral load measurement below 100 copies/ml in any transmission interval of the transmitter after ART start
After first viral suppression
     No viral load measured      No viral load measurement in any transmission interval of the transmitter after ART start
     No viral suppression      At least one viral load measurement at or above 100 copies/ml in any transmission interval of the transmitter after ART start
    Viral suppression, one observation     One viral load measurement in any transmission interval of the transmitter after ART start, which is below 100 copies/ml.
     Viral suppression, >1 observations      Several viral load measurements in any transmission interval of the transmitter after ART start, all of which are below 100 copies/ml.
Not in contact No patient record (last contact, clinic visit, CD4 measurement, viral load measurement) in the past and future 9 months from the midpoint of the transmission interval.

While flow through the stages is typically unidirectional, men could move freely between these stages.