Table 2. Stages in the HIV infection and care continuum.
| Infection/care stage of transmitter | Definition |
|---|---|
| Undiagnosed | Transmission intervals whose midpoint is before diagnosis: |
| Confirmed recent infection at diagnosis | All transmission intervals of transmitters that were in laboratory confirmed recent infection at time of diagnosis. |
| Estimated to be in recent infection | Considering transmitters that had no evidence for recent infection at time of diagnosis, all transmission intervals whose midpoint is less than 12 months after the estimated infection date. |
| Estimated to be in chronic infection | Considering transmitters that had no evidence for recent infection at time of diagnosis, all transmission intervals whose midpoint is more than 12 months after the estimated infection date. |
| Diagnosed | Transmission intervals whose midpoint is after diagnosis and before ART start (only of transmitters that are in contact with care services): |
| Diagnosed < 3mo, Recent infection at diagnosis | Considering potential or probable transmitters that were in laboratory confirmed recent infection at time of diagnosis, all transmission intervals whose midpoint is within the first three months after diagnosis. |
| No CD4 measured | No available CD4 count since diagnosis up to the midpoint of the interval. |
| CD4 > 500 | CD4 counts remained above 500 cells/ml between the first CD4 count up to the midpoint of the interval. |
| CD4 in [350-500] | CD4 counts decreased to 350-500 cells/ml between the first CD4 count up to the midpoint of the interval. |
| CD4 < 350 | CD4 counts decreased to below 350 cells/ml between the first CD4 count up to the midpoint of the interval. |
| ART initiated | Transmission intervals whose midpoint is after ART start (only of transmitters that are in contact with care services): |
| Before first viral suppression | No first viral load measurement below 100 copies/ml in any transmission interval of the transmitter after ART start |
| After first viral suppression¶ | |
| No viral load measured¶ | No viral load measurement in any transmission interval of the transmitter after ART start |
| No viral suppression¶ | At least one viral load measurement at or above 100 copies/ml in any transmission interval of the transmitter after ART start |
| Viral suppression, one observation¶ | One viral load measurement in any transmission interval of the transmitter after ART start, which is below 100 copies/ml. |
| Viral suppression, >1 observations¶ | Several viral load measurements in any transmission interval of the transmitter after ART start, all of which are below 100 copies/ml. |
| Not in contact | No patient record (last contact, clinic visit, CD4 measurement, viral load measurement) in the past and future 9 months from the midpoint of the transmission interval. |
While flow through the stages is typically unidirectional, men could move freely between these stages.