Skip to main content
. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Biochem Soc Trans. 2016 Jun 9;44(3):945–950. doi: 10.1042/BST20160035

Figure 3.

Figure 3.

iRhom triggers ERAD in flies but forward trafficking in mammals. In Drosophila the primary known function of iRhom is to trigger degradation of the EGF-like ligand Spitz by ERAD; it is not know if this function also occurs in mammalian cells. The known function in mammals is to promote the forward trafficking from the ER to the Golgi apparatus of TACE, the enzyme that activates TNFα and several EGFR ligands. In both flies and mammals, iRhom binds directly to its client protein, which has a single TMD.