Table 2.
Modulation of peptide binding through amino acid modification
| HLA allele | Modification | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
|---|---|---|---|---|---|---|---|---|---|---|
| HLA-A2 | Arg → Cit | NT | ND | + | ND | + | ND | – | + | ND |
| Gln → Glu | NT | ND | ND | + | + | – | ND | + | + | |
| Ser → pSer | NT | ND | + | + | ND | + | + | ND | + | |
| HLA-DQ8 | Arg →Cit | ND | NT | NT | ND | ND | – | ND | – | – |
| Gln → Glu | + | NT | NT | ND | ND | + | ND | – | + | |
| Ser → pSer | ND | NT | NT | – | ND | ND | – | ND | – | |
| HLA-DQ2 | Arg →Cit | – | NT | NT | – | – | – | – | – | ND |
| Gln → Glu | – | NT | NT | – | ND | + | ND | + | + | |
| Ser → pSer | – | NT | NT | ND | ND | ND | – | – | – | |
| HLA-DR0301 | Arg →Cit | + | NT | NT | ND | NT | – | + | NT | – |
| Gln → Glu | ND | NT | NT | ND | NT | – | – | NT | ND | |
| Ser → pSer | ND | NT | NT | ND | NT | – | – | NT | – | |
| HLA-DR0401 | Arg →Cit | ND | NT | NT | + | NT | ND | + | NT | + |
| Gln → Glu | ND | NT | NT | + | NT | ND | ND | NT | – | |
| Ser → pSer | ND | NT | NT | ND | NT | – | NT | NT | – |
+ a significant increase in binding affinity, – a significant decrease in binding affinity, ND no difference in binding affinity, NT not tested