Skip to main content
. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: Cell Rep. 2016 Mar 17;14(12):2833–2845. doi: 10.1016/j.celrep.2016.02.081

Figure 1.

Figure 1

See also Figure S1: 2B4βLα-CD3γε titration indicating Helix 3, Helix 4-F strand and FG loop as interacting regions: A) Illustration of 2B4 TCR, CD3γε and CD3δε components (in no specific orientation) with variable domains (Vα and Vβ), constant domains (Cα and Cβ) and complementarity determining regions (CDRs) indicated on the TCR B) Overlay of 15N-TROSY spectra of perdeuterated 15N-labeled 2B4βLα: deuterated unlabeled CD3γε ratios of 1:0 (green), 1:2 (cyan), 1:5 (orange) and 1:9 (red). C)-D) Zoomed-in view of the chemical shift perturbations of Q138, N205 and W200. E) Plot of peak intensities of Q138, N205 and W200 with increasing CD3γε.