Supplemental Table 6.
Analysis of Hepadnaviridae probes on viral microarray did not find evidence of HBV differentially expressed in pSS or in pSS that possessed HDV in salivary gland tissue relative to healthy controls.
| pSS versus Healthy Controls |
HDV+pSS versus Healthy Controls |
HDV-pSS versus Healthy Controls |
|||||
|---|---|---|---|---|---|---|---|
| Family Name | Probe Name | P (Corr) | FC | P (Corr) | FC | P (Corr) | FC |
| Hepadnaviridae | Hepadnaviridae_9626719_104 | 0.92 | 1.05 | 0.80 | 1.33 | 0.84 | -1.34 |
| Hepadnaviridae | Hepadnaviridae_48696569_109 | 0.88 | -1.25 | 0.80 | -1.69 | 0.85 | 1.26 |
| Hepadnaviridae | Hepadnaviridae_48696604_116 | 0.84 | -1.44 | 0.80 | -1.52 | 0.85 | -1.34 |
| Hepadnaviridae | Hepadnaviridae_22256030_12 | 0.72 | -1.23 | 0.80 | -1.21 | 0.84 | -1.26 |
| Hepadnaviridae | Hepadnaviridae_9630370_13 | 0.51 | -1.91 | 0.62 | -2.02 | 0.84 | -1.75 |
| Hepadnaviridae | Hepadnaviridae_21326584_14 | 0.88 | -1.15 | 0.91 | 1.08 | 0.84 | -1.59 |
| Hepadnaviridae | Hepadnaviridae_9630370_14 | 0.77 | 1.59 | 0.88 | 1.27 | 0.78 | 2.21 |
| Hepadnaviridae | Hepadnaviridae_9630370_15 | 0.88 | 1.20 | 0.80 | 1.42 | 0.91 | -1.08 |
| Hepadnaviridae | Hepadnaviridae_21326584_16 | 0.72 | -2.05 | 0.80 | -2.60 | 0.85 | -1.43 |
| Hepadnaviridae | Hepadnaviridae_21326584_16 | 0.72 | 1.38 | 0.80 | 1.37 | 0.84 | 1.38 |
| Hepadnaviridae | Hepadnaviridae_9628827_17 | 0.77 | 1.13 | 0.92 | -1.02 | 0.54 | 1.38 |
| Hepadnaviridae | Hepadnaviridae_48696604_18 | 0.91 | -1.23 | 0.80 | -1.53 | 0.91 | 1.13 |
| Hepadnaviridae | Hepadnaviridae_9626719_20 | 0.72 | 1.50 | 0.80 | 1.63 | 0.85 | 1.31 |
| Hepadnaviridae | Hepadnaviridae_9630370_20 | 0.72 | -1.15 | 0.80 | -1.06 | 0.78 | -1.31 |
| Hepadnaviridae | Hepadnaviridae_21326584_21 | 0.77 | -1.77 | 0.80 | -2.07 | 0.85 | -1.39 |
| Hepadnaviridae | Hepadnaviridae_22256030_22 | 0.76 | 1.29 | 0.80 | 1.45 | 0.86 | 1.08 |
| Hepadnaviridae | Hepadnaviridae_9628827_22 | 0.45 | 1.52 | 0.27 | 1.74 | 0.78 | 1.24 |
| Hepadnaviridae | Hepadnaviridae_9630370_23 | 0.91 | -1.16 | 0.92 | 1.06 | 0.85 | -1.60 |
| Hepadnaviridae | Hepadnaviridae_22256030_29 | 0.51 | 1.36 | 0.55 | 1.51 | 0.84 | 1.15 |
| Hepadnaviridae | Hepadnaviridae_9628827_29 | 0.45 | 1.52 | 0.27 | 1.79 | 0.84 | 1.18 |
| Hepadnaviridae | Hepadnaviridae_9628827_3 | 0.72 | 1.34 | 0.80 | 1.23 | 0.53 | 1.53 |
| Hepadnaviridae | Hepadnaviridae_9630370_3 | 0.98 | 1.01 | 0.91 | 1.11 | 0.85 | -1.15 |
| Hepadnaviridae | Hepadnaviridae_9628827_8 | 0.91 | 1.07 | 0.80 | -1.36 | 0.54 | 1.87 |
| Hepadnaviridae | Hepadnaviridae_9630370_8 | 0.92 | 1.06 | 0.91 | 1.11 | 0.99 | -1.01 |
| Hepadnaviridae | Hepadnaviridae_21326584_9 | 0.72 | 1.51 | 0.80 | 1.84 | 0.85 | 1.12 |
| Hepadnaviridae | Hepadnaviridae_22256030_9 | 0.77 | 1.25 | 0.88 | -1.12 | 0.48 | 2.06 |
| Hepadnaviridae | Hepadnaviridae_9630370_9 | 0.88 | 1.22 | 0.80 | 1.54 | 0.85 | -1.17 |
Evaluation of HBV transcripts as detected by the viral microarray showed no significant difference in HBV transcripts levels between pSS patient samples and healthy controls showed. Evaluation of just the 9 samples that presented with HDV probe intensity above the 99%CI of HDV probe intensity of the healthy controls did not reveal a differential expression in pSS with HDV in salivary gland tissue compared to healthy controls. No significant difference in HBV probe intensity was noted between the HDV-negative pSS patients and healthy controls. (n = 14-15, t-test, Benjamini-Hochberg correction (P Corr), was utilized to calculate statistical significance. FC = fold change)