Supplemental Table 6.

Analysis of Hepadnaviridae probes on viral microarray did not find evidence of HBV differentially expressed in pSS or in pSS that possessed HDV in salivary gland tissue relative to healthy controls.

		pSS versus Healthy Controls		HDV+pSS versus Healthy Controls		HDV-pSS versus Healthy Controls
Family Name	Probe Name	P (Corr)	FC	P (Corr)	FC	P (Corr)	FC
Hepadnaviridae	Hepadnaviridae_9626719_104	0.92	1.05	0.80	1.33	0.84	-1.34
Hepadnaviridae	Hepadnaviridae_48696569_109	0.88	-1.25	0.80	-1.69	0.85	1.26
Hepadnaviridae	Hepadnaviridae_48696604_116	0.84	-1.44	0.80	-1.52	0.85	-1.34
Hepadnaviridae	Hepadnaviridae_22256030_12	0.72	-1.23	0.80	-1.21	0.84	-1.26
Hepadnaviridae	Hepadnaviridae_9630370_13	0.51	-1.91	0.62	-2.02	0.84	-1.75
Hepadnaviridae	Hepadnaviridae_21326584_14	0.88	-1.15	0.91	1.08	0.84	-1.59
Hepadnaviridae	Hepadnaviridae_9630370_14	0.77	1.59	0.88	1.27	0.78	2.21
Hepadnaviridae	Hepadnaviridae_9630370_15	0.88	1.20	0.80	1.42	0.91	-1.08
Hepadnaviridae	Hepadnaviridae_21326584_16	0.72	-2.05	0.80	-2.60	0.85	-1.43
Hepadnaviridae	Hepadnaviridae_21326584_16	0.72	1.38	0.80	1.37	0.84	1.38
Hepadnaviridae	Hepadnaviridae_9628827_17	0.77	1.13	0.92	-1.02	0.54	1.38
Hepadnaviridae	Hepadnaviridae_48696604_18	0.91	-1.23	0.80	-1.53	0.91	1.13
Hepadnaviridae	Hepadnaviridae_9626719_20	0.72	1.50	0.80	1.63	0.85	1.31
Hepadnaviridae	Hepadnaviridae_9630370_20	0.72	-1.15	0.80	-1.06	0.78	-1.31
Hepadnaviridae	Hepadnaviridae_21326584_21	0.77	-1.77	0.80	-2.07	0.85	-1.39
Hepadnaviridae	Hepadnaviridae_22256030_22	0.76	1.29	0.80	1.45	0.86	1.08
Hepadnaviridae	Hepadnaviridae_9628827_22	0.45	1.52	0.27	1.74	0.78	1.24
Hepadnaviridae	Hepadnaviridae_9630370_23	0.91	-1.16	0.92	1.06	0.85	-1.60
Hepadnaviridae	Hepadnaviridae_22256030_29	0.51	1.36	0.55	1.51	0.84	1.15
Hepadnaviridae	Hepadnaviridae_9628827_29	0.45	1.52	0.27	1.79	0.84	1.18
Hepadnaviridae	Hepadnaviridae_9628827_3	0.72	1.34	0.80	1.23	0.53	1.53
Hepadnaviridae	Hepadnaviridae_9630370_3	0.98	1.01	0.91	1.11	0.85	-1.15
Hepadnaviridae	Hepadnaviridae_9628827_8	0.91	1.07	0.80	-1.36	0.54	1.87
Hepadnaviridae	Hepadnaviridae_9630370_8	0.92	1.06	0.91	1.11	0.99	-1.01
Hepadnaviridae	Hepadnaviridae_21326584_9	0.72	1.51	0.80	1.84	0.85	1.12
Hepadnaviridae	Hepadnaviridae_22256030_9	0.77	1.25	0.88	-1.12	0.48	2.06
Hepadnaviridae	Hepadnaviridae_9630370_9	0.88	1.22	0.80	1.54	0.85	-1.17

Evaluation of HBV transcripts as detected by the viral microarray showed no significant difference in HBV transcripts levels between pSS patient samples and healthy controls showed. Evaluation of just the 9 samples that presented with HDV probe intensity above the 99%CI of HDV probe intensity of the healthy controls did not reveal a differential expression in pSS with HDV in salivary gland tissue compared to healthy controls. No significant difference in HBV probe intensity was noted between the HDV-negative pSS patients and healthy controls. (n = 14-15, t-test, Benjamini-Hochberg correction (P Corr), was utilized to calculate statistical significance. FC = fold change)